Betahistine Pharmacology

Betahistine has a actual able affection as an adversary for histamine H3 receptors and a anemic affection as an agonist for histamine H1 receptors.

Betahistine has two mechanisms of action. Primarily, it a abounding agonist on the H1 receptors amid on claret argosy in the close ear. This gives acceleration to bounded vasodilation and added permeability, which helps to about-face the basal botheration of endolymphatic hydrops.

More importantly, betahistine has a able afraid furnishings at H3 receptors, thereby accretion the levels of neurotransmitters histamine, acetylcholine, norepinephrine, serotonin, and GABA appear from the assumption endings. The added amounts of histamine appear from histaminergic assumption endings can activate receptors. This dispatch explains the almighty vasodilatory furnishings of betahistine in the close ear, that are able-bodied documented.

Betahistine seems to amplify the claret argosy aural the close ear which can abate burden from balance aqueous and act on the bland muscle.

It is known that betahistine's access in the akin of serotonin in the brainstem inhibits the action of vestibular nuclei.