Carbenicillin Description

CAS: 4697-36-3

Molecular Formula: C17H18N2O6S

Molecular Weight: 378.4

Carbenicillin is a semisynthetic penicillin. Though carbenicillin provides abundant in vitro action adjoin a array of both gram-positive and gram-negative microorganisms, the a lot of important aspect of its contour is in its antipseudomonal and antiproteal activity. Because of the top urine levels acquired afterward administration, carbenicillin has approved analytic ability in urinary infections due to affected strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci.

Free carbenicillin is the absolute pharmacologically active atom of the salt. Carbenicillin exerts its antibacterial action by arrest with final corpuscle bank amalgam of affected bacteria. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal area by aperture the lactam ring. This inactivation of the agitator prevents the accumulation of a cross-link of two beeline peptidoglycan strands, inhibiting the third and endure date of bacterial corpuscle bank synthesis. Corpuscle lysis is again advised by bacterial corpuscle bank autolytic enzymes such as autolysins; it is accessible that carbenicillin interferes with an autolysin inhibitor.