CAS Number: 26864-56-2
Molecular Weight: 523.97
Molecular Formula: C28H27ClF5NO
Solubility: Soluble to 32 mg/mL in DMSO; Insoluble in
water
Storage: Store at 4° C
Penfluridol is a awful
potent, aboriginal bearing diphenylbutylpiperidine antipsychotic. It was
apparent at Janssen Pharmaceutica in 1968. Related to added
diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol
has an acutely continued abolishment half-life and its furnishings endure for
abounding canicule afterwards individual articulate dose. Its antipsychotic
potency, in agreement of dosage bare to aftermath commensurable effects, is
agnate to both haloperidol and pimozide. It is alone hardly sedative, but
generally causes extrapyramidal side-effects, such as akathisia, dyskinesiae
and pseudo-Parkinsonism. Penfluridol is adumbrated for antipsychotic analysis of
abiding schizophrenia and agnate certifiable disorders, it is, however, like a
lot of archetypal antipsychotics, getting more replaced by the aberant
antipsychotics. Due to its acutely abiding effects, it is generally assigned to
be taken orally as tablets alone already a anniversary (q 7 days). The
once-weekly dosage is usually 10–60 mg.
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