Alclometasone is a
constructed corticosteroid for contemporary dermatologic use. The
corticosteroids aggregate a chic of primarily constructed steroids acclimated topically
as anti-inflammatory and antipruritic agents. Alclometasone is a careful
glucocorticoid receptor agonist.
The apparatus of the
anti-inflammatory action of the contemporary steroids, in general, is unclear.
However, corticosteroids are anticipation to act by the consecration of
phospholipase A2 inhibitory proteins, collectively alleged lipocortins. It is
accepted that these proteins ascendancy the biosynthesis of almighty mediators
of deepening such as prostaglandins and leukotrienes by inhibiting the
absolution of their accepted precursor, arachidonic acid. Arachidonic acid is
appear from film phospholipids by phospholipase A2. Alclometasone initially
binds the corticosteroid receptor. This circuitous migrates to the basis area
it binds to altered glucocorticoid acknowledgment elements on the DNA. This in
about-face enhances and represses assorted genes, abnormally those complex in
anarchic pathways.
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