Annonacin is a
neurotoxic actinic admixture begin in some fruits such as the paw paw (custard
apple), soursop, and others from the ancestors Annonaceae. It is a affiliate of
the chic of compounds accepted as acetogenins.
Annonacin is a
neurotoxin that is believed to be amenable for the accident of aberant
parkinsonism in the Caribbean island of Guadeloupe area burning of soursop and
pawpaw is common. Studies in rodents indicates that burning of annonacin (3.8
and 7.6 mg per kg per day for 28 days) acquired academician lesions constant
with Parkinson's disease.
Along with added
acetogenins, annonacin blocks mitochondrial circuitous I (NADH-dehydrogenase),
which is amenable for the about-face of NADH to NAD+ and the accession of a
proton acclivity over the mitochondrial close membrane. This finer disables a
cell's adeptness to accomplish ATP via an oxidative pathway, ultimately
banishment a corpuscle into apoptosis or necrosis.
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