What is Piperonylic acid?

Piperonylic acid is a accustomed atom with a benzoic acid accumulation and top antioxidant capacity. Based on its ambrosial acid anatomy and antioxidant properties, we advised the furnishings of piperonylic acid on tyrosinase by the assay of its inhibitory kinetics and computational simulations.

Piperonylic acid reversibly inhibited tyrosinase through a mixed-type inhibitory mechanism. The time courses of the tyrosinase inhibition showed that piperonylic acid binds to tyrosinase actual bound and the inactivation processes chase first-order kinetics. The connected substrate reactions adumbrated that piperonylic acid induced a tight-binding inhibition and the substrate can advance the inactivation process.

The ANS-binding fluorescence of tyrosinase appropriate that piperonylic acid did not detectably agitate the tertiary anatomy of the enzyme. The after-effects of the computational advancing and atomic dynamics simulations showed that piperonylic acid carefully interacts with three residues and it ability block the alive website of tyrosinase.