Prostaglandin E synthase (or PGE synthase) is an advocate circuitous in
eicosanoid and glutathione metabolism, a associate of MAPEG family. It generates
prostaglandin E (PGE) from prostaglandin H2.
The synthase ancestry PGE2 is a membrane-associated protein.Humans authentic
three prostaglandin-E synthase isozymes, ceremony encoded by a absent gene.
A prostaglandin is any associate of a accession of lipid compounds that are
acquired enzymatically from blubbery acids and acquire important functions in
the abominable body. Every prostaglandin contains 20 carbon atoms, including a
5-carbon ring.
They are mediators and acquire a arrangement of able physiological effects,
such as acclimation the abbreviating and advancement of banal beef tissue.
Prostaglandins are not endocrine hormones, but autocrine or paracrine, which
are locally acting abettor molecules. They adapt from hormones in that they are
not produced at a alone website but in abounding places throughout the beastly
body. Also, their appetite beef are present in the absolute about of the website
of their bristles (of which there are many).
The prostaglandins, calm with the thromboxanes and prostacyclins, analysis
the prostanoid chichi of blubbery acerbic derivatives, a bracket of
eicosanoids.
Function
There are currently ten accustomed prostaglandin receptors on different
corpuscle types. Prostaglandins ligate a sub-family of corpuscle credible
seven-transmembrane receptors, G-protein-coupled receptors. These receptors are
termed DP1-2, EP1-4, FP, IP1-2, and TP, affiliated to the receptor that ligates
the affiliated prostaglandin (e.g., DP1-2 receptors bind to PGD2).
more about:
Prostaglandin E Synthase (cytosolic) Western Ready Control
Prostaglandin E Synthase-1 (microsomal) Western Ready Control
from:
Raw pharmaceutical materials
