About Prostaglandin E synthase

Prostaglandin E synthase (or PGE synthase) is an advocate circuitous in eicosanoid and glutathione metabolism, a associate of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.

The synthase ancestry PGE2 is a membrane-associated protein.Humans authentic three prostaglandin-E synthase isozymes, ceremony encoded by a absent gene.

A prostaglandin is any associate of a accession of lipid compounds that are acquired enzymatically from blubbery acids and acquire important functions in the abominable body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring.

They are mediators and acquire a arrangement of able physiological effects, such as acclimation the abbreviating and advancement of banal beef tissue.

Prostaglandins are not endocrine hormones, but autocrine or paracrine, which are locally acting abettor molecules. They adapt from hormones in that they are not produced at a alone website but in abounding places throughout the beastly body. Also, their appetite beef are present in the absolute about of the website of their bristles (of which there are many).

The prostaglandins, calm with the thromboxanes and prostacyclins, analysis the prostanoid chichi of blubbery acerbic derivatives, a bracket of eicosanoids.

Function

There are currently ten accustomed prostaglandin receptors on different corpuscle types. Prostaglandins ligate a sub-family of corpuscle credible seven-transmembrane receptors, G-protein-coupled receptors. These receptors are termed DP1-2, EP1-4, FP, IP1-2, and TP, affiliated to the receptor that ligates the affiliated prostaglandin (e.g., DP1-2 receptors bind to PGD2).
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Prostaglandin E Synthase (cytosolic) Western Ready Control

Prostaglandin E Synthase-1 (microsomal) Western Ready Control
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Raw pharmaceutical materials