Honokiol has apparent
pro-apoptotic furnishings in melanoma, sarcoma, myeloma, leukemia, bladder,
lung, prostate, articulate squamous corpuscle carcinoma, in glioblastome
multiforme beef and colon blight corpuscle lines. Honokiol inhibits
phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and
src. Additionally, honokiol regulates the nuclear agency kappa B (NF-κB)
activation pathway, an upstream effector of vascular endothelial advance agency
(VEGF), MCL1, and cyclooxygenase 2 (COX-2), all cogent pro-angiogenic and
adaptation factors. Honokiol induces caspase-dependent apoptosis in a
TRAIL-mediated manner, and potentiates the pro-apoptotic furnishings of
doxorubicin and added etoposides. So almighty is honokiol's pro-apoptotic
furnishings that it overcomes even awfully biologic aggressive neoplasms such
as assorted myeloma and abiding B-cell leukemia. Honokiol aswell acts on the
PI3K/mTOR alleyway in bump beef while advancement alleyway action in T cells.
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