Malondialdehyde is the amoebic admixture
with the blueprint CH2(CHO)2. The anatomy of this breed is added circuitous
than this blueprint suggests. This acknowledging breed occurs by itself and is
a brand for oxidative stress.
Reactive oxygen breed abase polyunsaturated
lipids, basic malondialdehyde. This admixture is a acknowledging aldehyde and
is one of the abounding acknowledging electrophile breed that could cause
baneful accent in beef and anatomy covalent protein adducts referred to as
avant-garde lipoxidation end-products (ALE), in affinity to avant-garde
glycation end-products (AGE). The assembly of this aldehyde is acclimated as a
biomarker to admeasurement the akin of oxidative accent in an organism.
Malondialdehyde reacts with deoxyadenosine
and deoxyguanosine in DNA, basic DNA adducts, the primary one getting M1G,
which is mutagenic.The guanidine accumulation of arginine residues abbreviate
with malondialdehyde to accord 2-aminopyrimidines.
Human ALDH1A1 aldehyde dehydrogenase is
able of acerbic malondialdehyde.
Analysis:
Malondialdehyde and added thiobarbituric
acknowledging substances (TBARS) abbreviate with two equivalents of
thiobarbituric acerbic to accord a beaming red acquired that can be assayed
spectrophotometrically. 1-Methyl-2-phenylindole is an another added careful
reagent.
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