CAS:
4342-03-4
Molecular
Formula: C6H10N6O
Molecular
Weight: 182.18
Dacarbazine
is an Alkylating Drug. The apparatus of activity of dacarbazine is as an
Alkylating Activity.Dacarbazine alkylates and cross-links DNA during all phases
of the corpuscle cycle, consistent in disruption of DNA function, corpuscle aeon
arrest, and apoptosis.After intravenous administering of dacarbazine, the
aggregate of administration exceeds absolute physique water agreeable
suggesting localization in some physique tissue, crystallinely the liver. Its
dematerialization from the blood is biphasic with antecedent half-life of 19
account and a terminal half-life of 5 hours. In a accommodating with renal and
hepatic dysfunctions, the half-lives were diffuse to 55 account and 7.2 hours.
The bromideplate accumulative elimination of banausic DTIC in the urine is 40%
of the injected dosage in 6 hours. DTIC is accountable to renal tubular beard
rather than glomerular filtration. At ameliorative concentrations dacarbazine
is not appreciably apprenticed to animal blood protein.
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