Glutathione Reductase Deficiency

Glutathione reductase deficiency is a attenuate ataxia in which the glutathione reductase action is absent from erythrocytes, leukocytes or both. In one abstraction this ataxia was empiric in alone two cases in 15,000 tests for glutathione reductase deficiency performed over the advance of 30 years. In the aforementioned study, glutathione reductase deficiency was associated with amaurosis and favism in one accommodating and their family, and with astringent unconjugated hyperbilirubinemia in addition patient. It has been proposed that the glutathione redox arrangement (of which glutathione reductase is a part) is about alone amenable for the attention of eye lens beef from hydrogen achromatize because these beef are amiss in catalase, an agitator which catalyzes the breakdown of hydrogen peroxide, and the top amount of avalanche accident in glutathione reductase amiss individuals.

Some patients display amiss levels of glutathione action as a aftereffect of not arresting abundant riboflavin in their diets. Riboflavin is a forerunner for FAD, whose bargain anmoleculey donates two electron to the disulfide band which is present in the breakable anmoleculey of glutathione reductase in adjustment to activate the enzyme's catalytic cycle. In 1999, a abstraction begin that 17.8% of males and 22.4% of females advised in Saudi Arabia suffered from low glutathione reductase action due to riboflavin deficiency.

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Human Glutathione Reductase (GR) ELISA Kit